While both pupusas and quesadillas are popular Mesoamerican dishes, they are distinct in taste, texture, and preparation. Pupusas are Salvadoran corn tortillas filled with cheese, beans, or meat, often served with curtido (a pickled cabbage slaw) and tomato salsa. Quesadillas, on the other hand, are Mexican dishes made with a flour or corn tortilla filled with cheese and sometimes other ingredients like vegetables or meat, folded in half, and grilled or cooked until crispy. While both are delicious, their unique flavors and cooking methods set them apart.